Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01
Running, not enrolling · Phase 2
Conditions studied: Head and Neck Squamous Cell Carcinoma
In brief
Master protocol: The main goal of this master clinical study is to evaluate the efficacy and safety of multiple novel combination therapies in participants with head and neck squamous cell carcinoma (HNSCC) in various substudies. Substudy-01 will evaluate the efficacy and safety of novel combination of treatment regimens, domvanalimab (DOM) and zimberelimab (ZIM) combined with chemotherapy vs ZIM combined with chemotherapy. The primary objective is to assess the efficacy of DOM and ZIM in combination with chemotherapy versus ZIM in combination with chemotherapy.
Key facts
- Study ID
- NCT06727565
- Run by
- Gilead Sciences
- People needed
- 100
- Starts
- 2025-02-18
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2026-03-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Siteman Cancer Center — St Louis, Missouri, United States
- Tennessee Oncology, PLLC - Greco-Hainsworth Centers for Research — Nashville, Tennessee, United States
- The University of Texas, MD Anderson Cancer Center — Houston, Texas, United States
- Westmead Hospital — Sydney, New South Wales, Australia
- ICON Cancer Center — Kurralta Park, South Australia, Australia
- Monash Health — Clayton, Victoria, Australia
- Alfred Health — Melbourne, Victoria, Australia
- Sichuan Cancer Hospital — Chengdu, China
- Zhejiang Cancer Hospital — Hangzhou, China
- Guangxi Medical University Cancer Hospital — Nanning, China
- Shanghai East Hospital — Shanghai, China
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, China
- CHU de Bordeaux — Pessac, France
- Fondazione IRCCS Istituto Nazionale dei Tumori — Milan, Italy
- Istituto Nazionale Tumori Fondazione G. Pascale — Naples, Italy
- Sarawak General Hospital — Sarawak, Malaysia
- Hospital Universitario Virgen del Rocio — Seville, Spain
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
- China Medical University Hospital — Taichung, Taiwan
- Taipei Veterans General Hospital — Taipei, Taiwan
- Chang Gung Memorial Hospital, Linkou — Taoyuan, Taiwan
- Barts Health NHS Foundation Trust — London, United Kingdom
- The Royal Marsden NHS Foundation Trust — London, United Kingdom
Full record on ClinicalTrials.gov
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