Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia

Recruiting now · Not applicable

Conditions studied: Ischemic Stroke, Acute, Acute Hemiparesis

In brief

The aim of this study is to demonstrate the effect of routine exercise program on neuroplasticity through histone acetylation and gene expression changes in acute stroke survivors from an epigenetic perspective and to investigate the correlation of epigenetic effects with its effects on motor function and quality of life.

Key facts

Study ID

NCT06726941

Run by

Afyonkarahisar Health Sciences University

People needed

48

Starts

2024-12-20

Expected to finish

2026-09-09

Last updated by the study team

2025-11-25

Who can join

Age: 25 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants who applied to Afyonkarahisar Health Sciences University Physical Therapy and Rehabilitation Clinic for rehabilitation purposes and had a stroke for the first time
• Participants with ischemia as the etiology of stroke
• Participants between the ages of 25-70
• Drugs that have been used for at least 1 month and up to 6 months after a cerebrovascular accident

You may not qualify if…

• Participants whose stroke etiology is other than ischemia
• Participants with clinically significant neurological disease other than stroke
• Participants with systemic and musculoskeletal diseases that will not tolerate neurological rehabilitation and prevent them from participating

Where it is running

• Afyonkarahisar Health Sciences University — Afyonkarahisar, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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