Neurosurgical Outcome Network

Recruiting now

Conditions studied: Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors, Moyamoya Disease, Dural Fistulas, Subdural Hematoma, Extradural Hematoma, Subarachnoid Hemorrhage, Hydrocephalus, Parkinson&Amp;#39;s Disease, Spasticity, Trigeminal Neuralgia, Craniofacial Pain, Neuropathic Pain, Tremor, Dystonias, Obsessive-compulsive Disorder, Drug-resistant Epilepsy, Depression, Normal Pressure Hydrocephalus, Tumors of Peripheral Nerves, Chiari Malformation Type 1

In brief

The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared. This study aims to assess outcomes and their predictors using measures agreed upon by the participating centers. Standardizing the evaluation of outcomes and predictors improves the quality of research, allows for data comparison, and facilitates a "common language" in routine clinical practice. Most importantly, it influences therapeutic decisions in various neurosurgical conditions. Clinically, the identified predictors can also be used during preoperative assessments to provide more precise guidance to patients undergoing surgery.

Key facts

Study ID

NCT06724029

Run by

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

People needed

4500

Starts

2022-12-05

Expected to finish

2027-06-01

Last updated by the study team

2026-03-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Neuro-oncological pathology: supratentorial and subtentorial tumors, intra and extra axial tumors excluding the skull base (anterior, middle and posterior fossa; sellar and parasellar region)
• Basicranial pathology: tumors originating from the anterior cranial fossa, middle cranial fossa and posterior cranial fossa, sellar region with or without supratentorial/parasellar development.
• Vascular pathology: aneurysms, AVMs, cavernomas, other pathologies (Moyamoya disease, dural fistulas, nontraumatic hematomas)
• Traumatic pathology: diffuse damage (nonvisible diffuse damage, diffuse damage, diffuse damage with edema, diffuse damage with shift) and focal damage (acute/subacute/chronic subdural hematoma, extradural hematoma, subarachnoid hemorrhage, intraparenchymal hematoma, fractures); hydrocephalus. The inclusion criterion for chronic subdural hematoma is recent bleeding for TBI with CT finding of chronic subdural hematoma candidate for evacuation surgery.
• Spinal pathology: degenerative cervical (anterior/posterior), myelopathic, and trauma pathology; instrumented, uninstrumented thoracolumbar pathology (disc pathology, canal pathology), and trauma pathology; oncologic spinal pathology.
• Functional pathology: Parkinson's disease, spasticity, trigeminal neuralgia, craniofacial pain/algia, neuropathic pain, tremor, dystonias, obsessive compulsive disorder, drug-resistant epilepsies, depression. Normotensive hydrocephalus.
• Peripheral nervous system pathology: peripheral nerve compression syndromes, peripheral nerve and plexus tumors, brachial plexus and peripheral nerve trauma (contusion and section)
• Malformative pathology: Chiari malformation type 1 and craniostenoses including both those framed in malformative syndromes and those not framed in malformative syndromes (monosutural craniostenoses: trigonocephaly, plagiocephaly, scaphocephaly; multisutural craniostenoses). Malformative hydrocephalus.
• For cognitive and psychological assessment: age 18 years or older; adequate understanding of Italian language; diagnosis of glioma, meningioma, vascular pathology, spinal pathology

You may not qualify if…

• For cognitive and psychological assessment: patients with psychiatric diseases in history and/or taking psychotropic drugs; presence of overt cognitive decline (not due to the injury) in history; patients younger than 18 years old.

Where it is running

• Ospedale F. Spaziani di Frosinone — Frosinone, Italy (enrolling)
• ASST Santi Paolo e Carlo — Milan, Italy (enrolling)
• Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco" — Catania, Italy (enrolling)
• Azienda Ospedaliero Universitaria Careggi — Florence, Italy (enrolling)
• Policlinico di Monza — Monza, Italy (enrolling)
• A.R.N.A.S. Ospedali Civico di Palermo — Palermo, Italy (enrolling)
• Ospedali Riuniti di Livorno -Azienda USL Toscana nord ovest — Livorno, Italy (enrolling)
• ASL Roma 1 — Roma, Italy (enrolling)
• Fondazione Policlinico Universitario Gemelli di Roma — Roma, Italy (enrolling)
• Fondazione IRCCS Istituto Neurologico Carlo Besta — Milan, Italy (enrolling)
• Azienda Sanitaria Universitaria Friuli Centrale di Udine — Udine, Italy (enrolling)
• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico — Milan, Italy
• ASST Fatebenefratelli Sacco — Milan, Italy
• Istituto Clinico Città Studi — Milan, Italy
• Azienda Ospedaliero Universitaria di Parma — Parma, Italy
• IRCCS Istituto Clinico Humanitas — Rozzano, Italy
• ASST Ovest Milanese — Legnano, Italy
• Spedali Civili Brescia — Brescia, BS, Italy
• Fondazione Poliambulanza Istituto Ospedaliero — Brescia, BS, Italy
• Ospedale Moriggia Pelascini — Gravedona, Como, Italy
• ASST Lariana, Ospedale S. Anna — Como, CO, Italy
• ASST Cremona — Cremona, CR, Italy
• Fondazione IRCCS San Gerardo dei Tintori — Monza, MB, Italy
• Fondazione IRCCS Policlinico San Matteo — Pavia, PV, Italy
• ASST della Valtellina ed Alto Lario — Sondrio, SO, Italy

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