The Collagen Factors of Rapid Progression of Keratoconus in Children.

Recruiting now

Conditions studied: Keratoconus

In brief

The purpose of this observational study was to understand the differences in clinical features and mechanisms of keratoconus between children and adults. The main questions it aimed to answer as follows: (1) to understand the characteristics of keratoconus in Chinese children. (2) to observe corneal stromal cells at the cytological level using in vivo corneal laser confocal microscopy and explore the pathogenesis.

Key facts

Study ID

NCT06722937

Run by

Zhongshan Ophthalmic Center, Sun Yat-sen University

People needed

160

Starts

2023-04-14

Expected to finish

2025-04-13

Last updated by the study team

2024-12-09

Who can join

Age: 10 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ① Patients with keratoconus who visit the refractive clinic.
• The height of the posterior corneal surface is greater than 16 microns under the Pentacam corneal topography.
• ARTAve < 424 microns, ARTMax < 339 microns.
• Clinical non-inflammatory or traumatic corneal thinning and corneal astigmatism.
• Aged between 10 and 50 years old, no gender restrictions.
• Agree to accept and complete follow-up examinations on time. ④ I and my guardian understand and agree to participate in this clinical trial and sign the informed consent form.

You may not qualify if…

• ① There is a history of contact lens wearing in the last four weeks.
• poor fixation and can not cooperate with the examination. ③ History of eye trauma and surgery (including corneal collagen cross-linking surgery).
• History of other related eye diseases: corneal disease, glaucoma, retinal choroid disease, etc..
• ⑤ severe eye diseases affecting imaging such as dry eye, conjunctivitis and pterygium.
• ⑥ Any systemic disease affecting eye morphology and refractive interstitium.

Where it is running

• Zhongshan Ophthalmic Center,Sun Yat-Sen University — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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