Mindfulness And Placebo for Pain (MAPP) Study
Running, not enrolling · Not applicable · Has a placebo group
Conditions studied: Chronic Pain
In brief
This study proposes a three-arm randomized-controlled trial (RCT) that evaluates the feasibility and acceptability of combining a mindfulness-based therapy (MBT) and open-label placebo (OLP) treatment for individuals with chronic pain. Individuals with chronic pain will be recruited to participate in an 8-week trial, with a subsequent 3-month post-treatment follow-up. Participants will be randomly assigned to one of the following three conditions: 1. Mindfulness-Based Stress Reduction (MBSR) 2. OLP treatment 3. combination of MBSR and OLP treatment
Key facts
- Study ID
- NCT06720909
- Run by
- Arizona State University
- People needed
- 45
- Starts
- 2025-01-27
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2026-07-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥18 years old;
- ability to speak, write, and read in English;
- physical pain present on at least half the days in the past 3 months; and
- average past week pain severity rating ≥3 on a 0-10 Numerical Rating Scale.
You may not qualify if…
- acute pain due to recent injury or surgery;
- self-reporting of chronic malignant pain (e.g., cancer, HIV);
- self-reporting of Raynaud's disease (those who can be contraindicated for cold pressor testing);
- severe psychopathology (e.g., a psychotic disorder) or significant cognitive deficits judged to interfere with study procedures;
- currently pregnant or breastfeeding;
- inability to discontinue use of vitamin B2 supplements or a multivitamin containing vitamin B2 throughout the study period (these interfere with riboflavin tracer-OLP treatment adherence-monitoring);
- inability to commit to study period.
Where it is running
- Arizona State University Downtown Phoenix Campus — Phoenix, Arizona, United States
- Arizona State University — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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