School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions

Recruiting now · Not applicable

Conditions studied: Rheumatic Heart Disease in Children

In brief

The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD. We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia. The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.

Key facts

Study ID

NCT06720272

Run by

Thomas Pilgrim

People needed

6000

Starts

2024-12-15

Expected to finish

2028-02-01

Last updated by the study team

2026-01-20

Who can join

Age: 5 and older, up to 16. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children aged 5-16 years

You may not qualify if…

• Children / primary caregivers not providing informed consent to participate
• Children not attending one of the selected schools

Where it is running

• National Academy od Medical Sciences — Kathmandu, Nepal (enrolling)
• Centre of Infectious Disease Research — Lusaka, Zambia (enrolling)

Full record on ClinicalTrials.gov

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