A Study of Doravirine and Islatravir as a Single Entity or Combination Therapy and the Effect of Food in Healthy Adult Participants (MK-8591A-055)

Completed · Phase 1

Conditions studied: Healthy

In brief

The purpose of this study is to learn what happens to MK-8591A in a person's body over time. Researchers will compare what happens to MK-8591A in the body when it is given with and without food.

Key facts

Study ID

NCT06719570

Run by

Merck Sharp & Dohme LLC

People needed

24

Starts

2024-01-23

Expected to finish

2024-03-15

Last updated by the study team

2024-12-06

Who can join

Age: 19 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Inclusion Criteria include, but are not limited to:
• Has a body mass index (BMI) ≥ 18.0 and ≤ 32.0 kg/m\^2
• Is medically healthy with no clinically significant medical history, physical examination, clinical laboratory profiles, vital signs, and electrocardiograms (ECGs)

You may not qualify if…

• Exclusion Criteria include, but are not limited to:
• Has a history or presence of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases
• Has a history of cancer (malignancy)

Where it is running

• Celerion (Site 0001) — Lincoln, Nebraska, United States

Full record on ClinicalTrials.gov

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