Risk Factors Associated With the Progression of Adenomyosis
Recruiting now
Conditions studied: Adenomyosis
In brief
Adenomyosis is a gynaecological disorder with a high prevalence in women of childbearing age and is characterised by the presence of endometrial glands and stroma within the myometrium, associated or not with hypertrophy and hyperplasia of the surrounding myometrium. Adenomyosis may cause pelvic pain and/or abnormal uterine bleeding. Transvaginal ultrasound (TVUS) is considered the main non-invasive diagnostic modality for the diagnosis of adenomyosis. Although adenomyosis is a very common condition among patients of childbearing age, its natural course is still debated. Some studies have evaluated the role of hormonal treatments (systemic or local oestrogen or progestin-based) on adenomyosis, which have been effective in controlling symptoms such as pelvic pain and abnormal uterine bleeding. Despite all this, no evidence is available on the progression of adenomyosis and the factors that may influence its progression over time. The aim of this study is therefore to assess the progression of adenomyosis and associated risk factors using transvaginal ultrasound.
Key facts
- Study ID
- NCT06718088
- Run by
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- People needed
- 258
- Starts
- 2022-06-01
- Expected to finish
- 2026-06-01
- Last updated by the study team
- 2024-12-05
Who can join
Age: 18 and older, up to 55. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged between 18 and 55 years;
- Presence of at least two direct and indirect signs according to the MUSA classification
- Obtaining informed consent
You may not qualify if…
- Patients undergoing hysterectomy;
- Virgo patients;
- Patients reporting intolerance to transvaginal ultrasound;
- Gynaecological oncology;
- Recent pregnancy or childbirth (within 6 months)
Where it is running
- IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Italy (enrolling)
Full record on ClinicalTrials.gov
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