Role of Interleukin 18 (IL-18) and Interleukin 18 Binding Protein (IL-18BP) in the Diagnostic Work-up of Systemic Juvenile Idiopathic Arthritis and Autoinflammatory Diseases: Possible Biomarkers in the Differential Diagnosis of Other Febrile Diseases

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Conditions studied: Systemic Juvenile Idiopathic Arthritis (sJIA)

In brief

Literature data suggest that elevated blood values of IL-18 and IL-18 Binding Protein and alterations in their ratio may be significantly correlated with various autoinflammatory diseases, such as systemic juvenile idiopathic arthritis, recurrent autoinflammatory fevers etc. In this view, the clinical implication of this observational, prospective, single-centre, non-pharmacological study will be the definition of new laboratory markers that may be useful in the early differential diagnosis of certain rare and serious paediatric diseases.

Key facts

Study ID

NCT06718049

Run by

IRCCS Azienda Ospedaliero-Universitaria di Bologna

People needed

9

Starts

2027-01-01

Expected to finish

2027-12-31

Last updated by the study team

2026-03-12

Who can join

Age: 2 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 2 years and 18 years;
• Being affected by 1 of the following: Juvenile Idiopathic Arthritis; recurrent fever/ autoinflammatory disease; rheumatic disease; severe infectious diseases (sepsis, meningitis, urinary tract infection, lower respiratory tract infection);
• Obtaining informed consent from parents/legal guardians of paediatric patients.

You may not qualify if…

• Patients in whom the suspicion of rheumatic disease is based on a finding of subclinical carditis or chorea.

Where it is running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Bologna, Italy

Full record on ClinicalTrials.gov

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