Efficacy of Adenosine as Compared to Verapamil in Paroxysmal Supraventricular Tachycardia (pSVT) Patients

Recruiting now · Phase 3

Conditions studied: Supraventricular Tachycardia (SVtach)

In brief

Supraventricular tachycardia (SVT) is a term widely used to describe tachycardial dysrhythmias, paroxysmal SVT (PSVT) is a narrow term including only AV nodal re-entrant tachycardia (AVNRT) and atrioventricular re-entrant tachycardia (AVRT), both of which can cause discomfort and, in some cases, life-threatening symptoms. Usually Carotid sinus massage is done to lower the pulse rate and after the standard time specific verapamil dose is administered. In this study after carotid sinus massage Conventional Valsalva or modified Valsalva maneuver will be randomly applied. In case, the normal sinus rhythm (NSR) is not achieved then verapamil of or adenosine dose will be administered to the patients after after taking the consent.

Key facts

Study ID

NCT06717685

Run by

Rashid Latif Medical College

People needed

210

Starts

2024-10-28

Expected to finish

2025-02-03

Last updated by the study team

2024-12-13

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Stable SVT (not requiring cardioversion, fully conscious, maintaining systolic blood pressure of >90mmHg)
• Alert enough and able to give consent
• Able to lie flat and non-painful legs during passive leg raising

You may not qualify if…

• Unstable SVT (Semiconscious, drowsy, breathless, systolic BP <90mmHg)
• Not able to give consent
• Orthopnea causing inability to lie flat
• Atrial fibrillation/atrial flutter
• Recent MI (within last 7 days)
• Ongoing ischemia as indicated by chest pain or ST segment depression/elevation in ECG
• Aortic stenosis
• All trimesters of pregnancy

Where it is running

• Punjab Institute of Cardiology — Lahore, Punjab Province, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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