Tissue Analysis of Liver Grafts as a Predictor of Transplant Outcome.
Recruiting now · Not applicable
Conditions studied: Hepatic Transplantation, Rejection; Transplant, Liver
In brief
Despite the good clinical results in terms of outcome with the application of HOPE prior to liver transplantation, very little is still known about the phenotypic and molecular changes that occur during perfusion/preservation during HOPE, particularly with regard to endothelial trophism and activation. Delving into these aspects would be very useful to allow personalised perfusion treatments in the future, thus improving the outcome of transplantation.
Key facts
- Study ID
- NCT06717542
- Run by
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- People needed
- 200
- Starts
- 2023-01-17
- Expected to finish
- 2028-01-01
- Last updated by the study team
- 2024-12-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- For Donors:
- Availability of enough tissue for histological, immunohistochemical and RT-PCR analysis.
- HOPE performed on the liver graft prior to transplantation.
- For Recipients:
- Availability of enough tissue for histological, immunohistochemical and RT-PCR analysis.
- Age greater than/equal to 18 years.
You may not qualify if…
- None
Where it is running
- IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Italy (enrolling)
Full record on ClinicalTrials.gov
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