Efficacy and Mechanism of Augmentation of Cognitive Behavioral Therapy With Transcranial Alternating Current Stimulation(tACS) for Obsessive-Compulsive Disorder (OCD)
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Obsessive Compulsive Disorder (OCD)
In brief
This study aims to evaluate the feasibility and clinical outcome of the Exposure-based Cognitive-Behavioral Therapy (CBT) concurrent with Transcranial Alternating Current Stimulation (tACS) using individualized stimulation frequency in treating obsessive-compulsive disorder (OCD) patients, and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).
Key facts
- Study ID
- NCT06717165
- Run by
- Shanghai Mental Health Center
- People needed
- 62
- Starts
- 2024-04-15
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-08-01
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18-60 years old
- With at least 9 years of education
- Y-BOCS score ≥16
- No history of serious medical, neurological illness or other psychotic disorders other than OCD (anxiety or mild to moderate depression secondary to OCD was not exclusionary)
- Medication-free or had received stable medication for at least 8 weeks before entering the study and continued the same medication throughout the study
You may not qualify if…
- History of serious medical, neurological illness or other psychotic disorders other than OCD
- OCD symptoms are severe, preventing the patient from completing the required assessment and examination
- Serious suicide risk
- Women who are pregnant or planning to become pregnant
- Currently taking antiepileptic medication
- Clinically significant physical illnesses or laboratory test abnormalities that have clinical significance
- Previous completion of a full course of CBT/ERP treatment
Where it is running
- Shanghai Mental Health Center — Shanghai, Shanghai Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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