Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

Completed · Phase 2 · Has a placebo group

Conditions studied: Primary Total Knee Arthroplasty, Intraosseous Morphine Injection, Knee Osteoarthritis

In brief

Study investigators propose to investigate if a bony injection of pain medication during a knee replacement will help pain levels following primary knee replacement surgery. To investigate this, 86 patients will be enrolled. Half of the patients will receive a bony injection of antibiotics with morphine (pain medication) while the other half will receive a bony injection of antibiotics with placebo (no pain medication). Following surgery, patient pain levels and pain medication consumption will be measured. The injection is intraosseous meaning in the bone. The needle pierces the bone and the medication is injected into the bone. The site of injection is on the anterior (front) of the upper portion of the tibia. The medications are Vancomycin (antibiotic) and Morphine (pain medication) which are mixed in separate syringes and then injected. Intraosseous vancomycin is standard of care while intraosseous vancomycin with morphine is also standard of care, depending on operating surgeon.

Key facts

Study ID

NCT06716749

Run by

Carilion Clinic

People needed

100

Starts

2024-12-01

Expected to finish

2025-06-02

Last updated by the study team

2025-09-10

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-100 years old
• Primary total knee arthroplasty
• Participants must be able to consent for themselves
• Capable and comfortable with text messaging

You may not qualify if…

• Non-primary total knee arthroplasty
• Intraoperative or postoperative deviation from standard of care
• Post-traumatic surgical indication
• Post-infectious surgical indication
• Chronic narcotic use or history of narcotic addiction
• Allergy to vancomycin
• Allergy to morphine
• Inability to receive spinal anesthesia
• Inability to receive intraoperative adductor canal block
• Inability to provide informed consent for the study
• Inability to speak English fluently

Where it is running

• Carilion Clinic — Roanoke, Virginia, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.