PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin
Recruiting now
Conditions studied: Acute Kidney Injury
In brief
The goal of this observational study is to know if, in patients with acute kidney injury, naive for renal injurie, admitted to different ICUs, the change in plasma concentration of c-cistatin, between initiation and discontinuation of CRRT, is a predictive finding to optimize the withdrawal time of renal support
Key facts
- Study ID
- NCT06714214
- Run by
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- People needed
- 152
- Starts
- 2024-10-01
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2024-12-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age ≥ 18 years;
- diagnosis of acute kidney injury (defined according to KDIGO 2012 criteria)
- need for support with CRRT according to the indications of the nephrologist consultants and Clinical Practice
- Obtaining informed consent
You may not qualify if…
- CRRT already ongoing (in another department not participating in the study) at the time of transfer/admission to intensive care;
- need for RRT (any type and modality) in the 14 days prior to enrolment;
- diagnosis of AKD/CKD/ESRF on admission;
- Discontinuation of CRRT under conditions that do not comply with the criteria established by the study;
- Need for CRRT not associated with AKI condition (e.g. elimination of toxicants);
- pregnant women;
- presence of known thyreopathy
- Continuous use of corticosteroids
- patient with known neoplastic disease.
Where it is running
- IRCCS Azienda Ospedaliero-Universitaria di Bologna - Anestesia e Terapia Intensiva nelle emergenze locali, regionali e nazionale e nella chirurgia addominale maggiore — Bologna, Italy (enrolling)
- IRCCS Azienda Ospedaliero-Universitaria di Bologna -Anestesiologia e terapia intensiva polivalente — Bologna, Italy (enrolling)
Full record on ClinicalTrials.gov
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