Extracellular Vesicles in Fibrin Gel for Cartilage Repair

Recruiting now

Conditions studied: Joint Disease

In brief

This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth of PRP growth factors and the hyaline cartilage stimulating activity of MSC-EVs. Therefore, the project goal is to provide an advanced option for orthopedic patients with an innovative evolution of a gold standard procedure, making it easy to translate into daily clinical practice for physicians, healthcare professionals and patients.

Key facts

Study ID

NCT06713902

Run by

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

People needed

51

Starts

2024-10-29

Expected to finish

2026-08-30

Last updated by the study team

2024-12-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• males and females ≥ 18
• patients undergoing plastic surgery procedures;
• patients undergoing elective joint surgery with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade);
• patients undergoing regenerative medicine treatments with PRP with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade;
• signed Informed Consent for the study

You may not qualify if…

• Positive virological test (HIV, HCV, HBV, TPHA)
• Pregnancy or breastfeeding by self-declaration
• Other conditions that, at the discretion of the investigator or the physician

Where it is running

• I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio — Milan, MI, Italy (enrolling)

Full record on ClinicalTrials.gov

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