Noninvasive Brain Stimulation in Adult Amblyopia
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Amblyopia
In brief
The goal of this randomized controlled trial is to investigate the effectiveness of non-invasive brain stimulation in treating adults with amblyopia. The main questions it aims to answer are: 1. What are the effects of non-invasive brain stimulation on neuronal plasticity in the visual cortex of adults with amblyopia, and does it produce lasting changes? 2. Do cumulative sessions of non-invasive brain stimulation influence neural plasticity and higher-order visual functions in adults with amblyopia? The investigators hypothesize that non-invasive brain stimulation will show a positive cumulative effect after five (5) consecutive days of stimulation on visual perception and function in adults with amblyopia. Participants will be randomized into one of two treatment groups: 1. High-frequency transcranial random noise stimulation (hf-tRNS). 2. Sham stimulation. Researchers will compare baseline measurements of crowded visual acuity, contrast sensitivity, stereoacuity, phosphene thresholds, global motion perception, form pattern recognition and pattern-reversal visual evoked potentials (VEPs) to post-treatment measurements for each group.
Key facts
- Study ID
- NCT06712849
- Run by
- Midwestern University
- People needed
- 60
- Starts
- 2024-05-01
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2024-12-12
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults between 18 and 55 years of age
- Formal diagnosis of amblyopia in one or both eyes of any etiology
You may not qualify if…
- History of optic nerve disease, including glaucoma and optic neuritis
- History of neurological conditions, including demyelinating disease or stroke
- Presence of metal or electronic implants in or on the body, including pacemakers
- Taking medications that can affect normal neurological function, including antipsychotics, antiepileptics, and opioids
Where it is running
- Midwestern University Eye Institute — Downers Grove, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
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