A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING

Recruiting now

Conditions studied: Moderate to Severe Rheumatoid Arthritis

In brief

This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany. Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.

Key facts

Study ID

NCT06712628

Run by

AbbVie

People needed

678

Starts

2024-11-07

Expected to finish

2028-12-01

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current or Past participants with a confirmed diagnosis of moderate to severe active RA upon judgement of the treating physician.
• Physician decision on participant treatment with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) must have been reached prior to and independently of recruitment in the study
• UPA or TNFi prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies

You may not qualify if…

• Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug [whichever is longer] prior to baseline)
• Prior treatment with Upadacitinib
• Prior treatment with the same tumor necrosis factor inhibitor as the one prescribed for this study

Where it is running

• Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587 — Planegg, Bavaria, Germany (enrolling)
• Medikomp Mvz /ID# 285898 — Elsterwerda, Brandenburg, Germany (enrolling)
• Private Practice - Dr. Dirk Wernicke /ID# 276820 — Hohen Neuendorf, Brandenburg, Germany (enrolling)
• Praxis K. Pagel /ID# 279121 — Hoppegarten, Brandenburg, Germany (enrolling)
• Rheumahaus Studien GbR /ID# 275917 — Potsdam, Brandenburg, Germany (enrolling)
• Rheumatologisch Immunologisch /ID# 275830 — Templin, Brandenburg, Germany (enrolling)
• Rheumatism Center Mittelhessen /ID# 274641 — Bad Endenbach, Hesse, Germany (enrolling)
• Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291 — Frankfurt am Main, Hesse, Germany (enrolling)
• Mvz Dr. Med. Mahdy and Kollegen - Braunschweig /ID# 284988 — Braunschweig, Lower Saxony, Germany (enrolling)
• Stadtisches Klinikum Braunschweig /ID# 282626 — Braunschweig, Lower Saxony, Germany (enrolling)
• Private Practice - Dr. Jorg Sensse /ID# 281907 — Gifhorn, Lower Saxony, Germany (enrolling)
• Rheumatologische Facharztpraxis /ID# 286591 — Hanover, Lower Saxony, Germany (enrolling)
• Rheumapraxis Hannover-List /ID# 273735 — Hanover, Lower Saxony, Germany (enrolling)
• Praxis. F. Bigdeli-Wilshusen /ID# 273455 — Hanover, Lower Saxony, Germany (enrolling)
• Rheumatologie Kassel /ID# 275916 — Kassel, Lower Saxony, Germany (enrolling)
• Rheumapraxis An Der Hase /ID# 276949 — Osnabrück, Lower Saxony, Germany (enrolling)
• Fachpraxis fur Rheumatologie und Osteologie /ID# 275359 — Weyhe, Lower Saxony, Germany (enrolling)
• Dr. Ann-Dorthe Holst /ID# 285741 — Ludwigslust, Mecklenburg-Vorpommern, Germany (enrolling)
• Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367 — Neubrandenburg, Mecklenburg-Vorpommern, Germany (enrolling)
• Rheumatologische Facharztpraxis - Schwerin /ID# 284785 — Schwerin, Mecklenburg-Vorpommern, Germany (enrolling)
• Klinikum Bielefeld Rosenhohe /ID# 283715 — Bielefeld, North Rhine-Westphalia, Germany (enrolling)
• Rheumatology Euskirchen /ID# 285419 — Euskirchen, North Rhine-Westphalia, Germany (enrolling)
• Rheumazentrum Ruhrgebiet /ID# 275518 — Herne, North Rhine-Westphalia, Germany (enrolling)
• St.Elisabeth Hospital Meerbusch /ID# 275030 — Meerbusch, North Rhine-Westphalia, Germany (enrolling)
• Praxiszentrum Dr. Med. Klaus Kruger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138 — Munich, Bavaria, Germany (enrolling)

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