Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma

Recruiting now

Conditions studied: Transformed Splenic Marginal Zone Lymphoma

In brief

Histological transformation in Splenic Marginal Zone Lymphoma (t-SMZL) represents an unmet clinical and biological need, invariably associated with poor prognosis and reduced overall survival. At the present time, there are no recommended treatments intended specifically to t-SMZL and little is known about t-SMZL genetic complexity. The aim of this study is to provide information that will help clinicians to better understand the complexity of the disease. The information gained from this study will also lead to more specific and effective treatment for patients with t-SMZL.

Key facts

Study ID

NCT06712459

Run by

International Extranodal Lymphoma Study Group (IELSG)

People needed

100

Starts

2025-10-13

Expected to finish

2029-03-01

Last updated by the study team

2026-01-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years or older, regardless of the gender;
• Diagnosis of HT of SMZL (both at baseline, co-occurring with diagnosis of SMZL, or during the natural history of the disease);
• Availability of diagnostic tumor material (either frozen or FFPE) from spleen, lymph node, extra nodal site, peripheral blood or bone marrow collected at the time of histological transformation. Tumor material (either frozen or FFPE), from spleen, peripheral blood or bone marrow, collected at the time of SMZL diagnosis will be also collected, if available;
• Availability of the baseline and follow-up annotations.

You may not qualify if…

• None

Where it is running

• Fondazione IRCCS Policlinico San Matteo — Pavia, Italy (enrolling)
• Hôpital Saint Louis — Paris, France (enrolling)
• Hospital Clínic de Barcelona — Barcelona, Spain (enrolling)
• Columbia University — New York, New York, United States
• University Hospitals Dorset — Bournemouth, United Kingdom
• Universitz Hospitals Leuven — Leuven, Belgium
• Oncology Institute of Southern Switzerland — Bellinzona, Switzerland

Full record on ClinicalTrials.gov

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