Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)

Starting soon · Phase 2

Conditions studied: Sarcoma,Soft Tissue

In brief

This trial will investigate the combination of two low-cost, non-toxic strategies to assess whether they can reduce the risk of acute major wound complications in soft tissue sarcoma of the lower extremity. Intranasal mupirocin ointment twice daily and chlorhexidine body cleanser once daily for 5 days prior to radiation therapy and repeated for 5 days every 2 weeks during radiation therapy may significantly reduce the risk of acute radiation dermatitis. That, along with use of indocyanine green (ICG) angiography at the time of wound closure.

Key facts

Study ID

NCT06712433

Run by

Adam Olson

People needed

31

Starts

2026-09-30

Expected to finish

2028-09-30

Last updated by the study team

2026-02-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2
• Newly diagnosed soft tissue sarcoma arising from the lower extremity (defined as the tumor center arising at the level of the iliac crest or below)
• Eligible for wide local excision
• Eligible for external beam radiation therapy
• Negative serum pregnancy test for women of childbearing potential < 28 days prior to RT.
• Informed consent signed and dated to participate in the study.
• Willingness and ability to comply

You may not qualify if…

• Allergy to mupirocin and/or chlorhexidine
• Active dermatologic condition in RT field
• Tumor size > 32cm
• Prior RT overlapping with fields
• Concurrent/prior invasive malignancy that could potentially interfere with proposed treatment. Individual cases can be discussed with PI prior to registration

Where it is running

• UPMC Hillman Cancer Centers — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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