Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
Recruiting now · Phase 2/Phase 3
Conditions studied: Non-small Cell Lung Cancer
In brief
This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC). This study includes two substudies (substudy A and substudy B) that will recruit participants according to histological subtypes due to differences in chemotherapy choice for standard-of-care and type of NSCLC.
Key facts
- Study ID
- NCT06712316
- Run by
- BioNTech SE
- People needed
- 1260
- Starts
- 2025-01-07
- Expected to finish
- 2030-03-01
- Last updated by the study team
- 2026-07-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alaska Oncology and Hematology, LLC — Anchorage, Alaska, United States (enrolling)
- John Muir Clinical Research Center — Concord, California, United States (enrolling)
- University Of California - San Diego Moores Cancer Center — La Jolla, California, United States (enrolling)
- Clermont Oncology Center — Clermont, Florida, United States (enrolling)
- Mid Florida Cancer Centers — Orange City, Florida, United States (enrolling)
- Cleveland Clinic Florida - Martin North Hospital — Stuart, Florida, United States (enrolling)
- H. Lee Moffit Cancer center and research institute — Tampa, Florida, United States (enrolling)
- Cleveland Clinic Weston Hospital — Weston, Florida, United States (enrolling)
- Fort Wayne Medical Oncology and Hematology, Inc. — Fort Wayne, Indiana, United States (enrolling)
- Physicians Clinic of Iowa — Cedar Rapids, Iowa, United States (enrolling)
- Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States (enrolling)
- Baptist Health Hardin — Elizabethtown, Kentucky, United States (enrolling)
- Frederick Health Hospital- James M Stockman Cancer Institute — Frederick, Maryland, United States (enrolling)
- Missouri Cancer Associates — Columbia, Missouri, United States (enrolling)
- SSM Health Cancer Care - St. Clare — Fenton, Missouri, United States (enrolling)
- Mary Lanning Healthcare (MLH) - Morrison Cancer Center (MCC) — Hastings, Nebraska, United States (enrolling)
- Astera Cancer Care — East Brunswick, New Jersey, United States (enrolling)
- Summit Medical Group PA — Florham Park, New Jersey, United States (enrolling)
- The Valley Hospital - Valley Health System - The Robert and Audrey Luckow Pavilion — Paramus, New Jersey, United States (enrolling)
- Suny-Stony Brook University Cancer Center — Stony Brook, New York, United States (enrolling)
- White Plains Hospital — White Plains, New York, United States (enrolling)
- Fletcher Hospital, Inc. dba AdventHealth Hendersonville — Hendersonville, North Carolina, United States (enrolling)
- Gabrail Cancer Center Research — Canton, Ohio, United States (enrolling)
- The Christ Hospital Cancer Center — Cincinnati, Ohio, United States (enrolling)
- Birmingham Hematology and Oncology Associates LLC d/b/a Alabama Oncology — Birmingham, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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