Effect of Dexmedetomidine on Hemodynamic Response to Endotracheal Intubation in Hypertensive Patients

Recruiting now · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Elective Surgical Patient, Hypertensive Patients, Blood Pressure, Hypertensive Elderly Patients, Anxiolytic

In brief

Dexmedetomidine, an alpha-2 adrenergic agonist, has been shown to provide several benefits during endotracheal intubation: 1. \_Reduced anxiety and stress\_: Dexmedetomidine's anxiolytic and sedative effects help reduce anxiety and stress associated with endotracheal intubation. 2. \_Improved intubating conditions\_: Dexmedetomidine can improve intubating conditions by reducing the incidence of coughing, bucking, and laryngospasm. 3. \_Decreased hemodynamic responses\_: Dexmedetomidine can attenuate the hemodynamic responses to intubation, including tachycardia, hypertension, and increased cardiac output. 4. \_Increased ease of intubation\_: Dexmedetomidine can facilitate smoother and easier intubation by reducing the need for additional anesthetics or muscle relaxants. The physiological responses to dexmedetomidine during intubation include: 1. \_Decreased heart rate\_: Dexmedetomidine can cause a decrease in heart rate due to its effects on the sympathetic nervous system. 2. \_Decreased blood pressure\_: Dexmedetomidine can also cause a decrease in blood pressure due to its vasodilatory effects. 3. \_Increased sedation\_: Dexmedetomidine's sedative effects can help reduce anxiety and stress during intubation. 4. \_Reduced respiratory rate\_: Dexmedetomidine can cause a decrease in respiratory rate due to its effects on the respiratory centers in the brain. The clinical benefits of dexmedetomidine during intubation include: 1. \_Improved patient comfort\_: Dexmedetomidine's sedative and anxiolytic effects can improve patient comfort during intubation. 2. \_Reduced need for additional anesthetics\_: Dexmedetomidine can reduce the need for additional anesthetics or muscle relaxants during intubation. 3. \_Decreased risk of complications\_: Dexmedetomidine's effects on hemodynamic responses and respiratory rate can decrease the risk of complications during intubation.

Key facts

Study ID

NCT06712186

Run by

Liaquat National Hospital & Medical College

People needed

60

Starts

2024-06-22

Expected to finish

2024-12-01

Last updated by the study team

2024-12-11

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA Grade II
• Age > 60 years
• Elective surgical procedures under GA.
• All patients with a diagnosis of hypertension for 6 months or more and undergoing treatment with antihypertensive medications.

You may not qualify if…

• Patient refusal
• ASA Grade III and IV
• Severely Hypovolemic state
• Emergency surgeries
• Body weight more than 20% of ideal body weight.
• Patients with known or unanticipated difficult intubation and those requiring more than 15 sec or two attempts at laryngoscopy
• Allergic to dexmedetomidine
• Non complaint hypertensive patients
• Patients with uncontrolled hypertension.

Where it is running

• Liaquat National Hospital and Medical College — Karachi, Sindh, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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