Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）

Recruiting now · Not applicable

Conditions studied: Tumor, Stroke

In brief

This is a randomized controlled study to explore whether perioperative blood pressure management with different strategies can reduce the incidence of delirium and postoperative cognitive impairment and serious perfusion related complications (persistent hypotension, new heart arrhythmia, cardiac insufficiency, new stroke, sudden death, etc.) within 30 days after stroke in cancer patients at high risk for stroke. Patients were randomly divided into: 1) strict blood pressure management group: norepinephrine or phenylephrine maintenance intraoperative MAP≥85 mmHg, and 2) conventional blood pressure management group: intraoperative routine blood pressure management (MAP≥65mmHg). The study included 424 subjects and was randomized to provide 90% efficacy. Secondary markers were unscrupulous cerebrovascular events (persistent hypotension, arrhythmia, cardiac insufficiency, new stroke, sudden death) within 30 days after surgery.

Key facts

Study ID

NCT06711432

Run by

Zhejiang Cancer Hospital

People needed

214

Starts

2024-09-18

Expected to finish

2026-06-01

Last updated by the study team

2024-12-02

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with high-risk stroke (combined with 3 risk factors or more according to the stroke risk screening table)
• Patients who plan to undergo surgery for abdominal tumors (gynecological, urinary, hepatobiliary, and gastrointestinal tumors) under general anesthesia are expected to have surgery duration >2 hours
• The ASA is rated as Class II or III
• Patients who underwent invasive arterial blood pressure monitoring before surgery signed informed consent

You may not qualify if…

• Patients do not want to participate in the study
• Patients with severe heart disease (severe valvular disease, sick sinus syndrome, high atrioventricular block without pacemaker implantation), grade III or above Liver function impairment (Child-Pugh class C)
• Need kidney replacement therapy; New stroke <3 months
• Emergency surgery
• Preoperative history of mental illness, epilepsy, Parkinson's disease, or myasthenia gravis
• Speech, vision, or hearing impairment that prevents completion of a cognitive function assessment
• Situations where strict blood pressure management is not appropriate, such as controlled hypotension during surgery.

Where it is running

• Zhejiang Cancer Hospital — Hangzhou, Zhejiang, China (enrolling)

Full record on ClinicalTrials.gov

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