Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO)
Recruiting now · Phase 4
Conditions studied: Polypoidal Choroidal Vasculopathy
In brief
The goal of this clinical trial is to assess the efficacy, safety and durability of faricimab in caucasian patients with polypoidal choroidal vasculopathy (PCV). The main question it aims to answer is: To evaluate the efficacy of intravitreal (IVT) injections of faricimab 6 milligrams (mg) on Best Corrected Visual Acuity (BCVA) outcomes in caucasian patients with symptomatic macular PCV. Participants will undergo ophthalmic examination, safety assessment and treatment with faricimab according to a patient specific treat and extend regimen.
Key facts
- Study ID
- NCT06709339
- Run by
- Association for Innovation and Biomedical Research on Light and Image
- People needed
- 120
- Starts
- 2025-08-06
- Expected to finish
- 2028-08-01
- Last updated by the study team
- 2026-02-06
Who can join
Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Serviço Oftalmologia, Centro Hospitalar Universitário de Santo António, E.P.E., — Porto, Portugal (enrolling)
- Centro de Oftalmologia Barraquer — Barcelona, Spain (enrolling)
- Espaço Médico de Coimbra — Coimbra, Portugal (enrolling)
- Institut Català de Retina (ICR), Clinical Trial Unit — Barcelona, Spain (enrolling)
- Ophthalmology Department, Hospitais Universidade de Coimbra, — Coimbra, Portugal (enrolling)
- Unidade Local de Saúde da Região de Leiria, E.P.E. — Leiria, Portugal (enrolling)
- almPRIMUM- Serviços de Oftalmologia Médica e Cirúrgica — Lisbon, Portugal (enrolling)
- Instituto de Retina e Diabetes Ocular de Lisboa (IRL), — Lisbon, Portugal (enrolling)
- Serviço de Oftalmologia, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria — Lisbon, Portugal (enrolling)
- Clinical Trial Unit, Dep. Ophth., Gloucestershire Hospitals NHS Foundation Trust, — Gloucester, United Kingdom (enrolling)
- Clinical Eye Research Centre - St. Paul's Eye Unit, Royal Liverpool University Hospital — Liverpool, United Kingdom (enrolling)
- Clinical Trial Unit, Dep. Ophth., Gloucestershire Hospitals NHS Foundation Trust — London, United Kingdom (enrolling)
- Unidade Local de Saúde São José — Lisbon, Portugal (enrolling)
- University Hospital Southampton NHS Foundation Trust — Southampton, United Kingdom (enrolling)
- ULS-LOD - Hospital Beatriz Ângelo — Loures, Portugal (enrolling)
- IRCCS Fondazione G.B. Bietti per lo Studio e la Ricerca in Oftalmologia ONLUS, — Roma, Italy (enrolling)
- Wolverhampton and Midland Counties Eye Infirmary, New Cross Hospital — Wolverhampton, United Kingdom
- Medical Retina Service, Operative Unit Ophthalmology - MultiMedica Spa (IRCCSMM) — Milan, Italy
- ASST-Fatebenefratelli-Sacco P.O.L. Sacco — Milan, Italy
- Eye Unit, University Hospital Maggiore della Carità — Novara, Italy
- Department of Ophthalmology, University Vita Salute - Scientific Institute of San Raffaele — San Raffaele, Italy
- Department of Ophthalmology, University of Udine — Udine, Italy
- Department of Ophthalmology, Porto Medical School / Hospital S. João — Porto, Portugal
- Hospital Vall d'Hebrón Department of Ophthalmology — Barcelona, Spain
- Valles Ophthalmology Research, S.L., Hospital General de Catalunya, — Barcelona, Spain
Full record on ClinicalTrials.gov
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