The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation
Recruiting now · Phase 4
Conditions studied: Socket Preservation
In brief
This study is a randomized controlled trial comparing the effects of socket grafting with crushed vitamin K2 (menaquinone)capsules versus no grafting on bone density and socket dimensions following tooth extraction. Patients are randomly assigned to one of two groups: Study Group (Group I): Patients receive socket grafting with crushed vitamin K2 (menaquinone) capsules. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed to stabilize the graft material and achieve soft tissue stability. Control Group (Group II): Patients undergo socket healing without grafting. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed over it. Outcome measures include bone socket dimensions evaluated immediately after extraction with graft material, as well as assessment after 4 months using cone beam computed tomography (CBCT) radiographs. Additionally, core biopsies are taken at the time of implant placement.
Key facts
- Study ID
- NCT06707909
- Run by
- Cairo University
- People needed
- 20
- Starts
- 2025-02-15
- Expected to finish
- 2025-11-24
- Last updated by the study team
- 2025-02-05
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- • Patients with systemic conditions affecting bone metabolism.
- Allergies or sensitivities to hydroxyapatite or Vitamin K2
- Untreated or residual periodontal disease;
- Uncontrolled diabetes (HbA1c > 7.5%);
- Head and/or neck radiotherapy
- Immunosuppressive therapy
- Pregnant or nursing
- Substance abuse
- Treated or under treatment with intravenous amino-bisphosphonates
- Patients participating in other studies, if the present protocol could not be properly followed.
Where it is running
- Cairo — Cairo, Cairo Governorate, Egypt (enrolling)
Full record on ClinicalTrials.gov
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