NSCLC Liquid Biopsies and Exhaled VOC

Recruiting now

Conditions studied: Lung Cancer, Circulating Tumor DNA

In brief

The objective of the study is to determine the feasibility of recruiting participants and using sputum, Bronchoalveolar lavage (BAL) and exhaled Volatile Organic Compounds (VOC) in addition to blood, as biological samples for detecting mutations in extracted cell-free DNA in non-small cell lung cancer (NSCLC) patients, before and after surgery, and any recurrence within a 24-month postoperative follow-up period. This is a pilot feasibility study, proposed as a 24-month prospective, single-center, non-interventional, observational trial with NSCLC-adenocarcinoma patients indicated for resection surgery with curative intent.

Key facts

Study ID

NCT06707519

Run by

St. Joseph's Healthcare Hamilton

People needed

210

Starts

2023-02-01

Expected to finish

2027-12-29

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must be at least 18 years of age
• Patient must be able to provide consent
• Patients undergoing surgical resection with curative intent for non-small cell lung cancer at St. Joseph's Healthcare Hamilton and Firestone Institute for Respiratory Health.

You may not qualify if…

• Resection done with non-curative intent or metastatic disease
• other malignancies
• Patients with previously treated malignancy less than 5 years prior to current resection (not including skin cancer).

Where it is running

• St. Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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