Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Depression
In brief
To evaluate the efficacy of metformin as an adjunct therapy in improving depressive symptoms and metabolic markers in newly diagnosed obese depressed patients on standard antidepressant therapy. investigator will compare between Two groups 1\. metformin group 2 placebo group Primary outcome measure will be the improvement in depressive symptoms, indicating by a reduction in Hamilton Depression Rating Scale (HAM-D) scores. Secondary outcome measures will include the assessment of oxidative stress markers, specifically by measuring the increase in enzymatic activity of superoxide dismutase, catalase, and glutathione peroxidase Investigators hypothesize that the addition of metformin to standard antidepressant treatment will result in a significant reduction in symptoms of depression among newly diagnosed obese individuals.
Key facts
- Study ID
- NCT06707012
- Run by
- Fazaia Ruth Pfau Medical College
- People needed
- 140
- Starts
- 2025-10-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-09-19
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- • Age >18 to <45 years
- Gender: Both genders (Male and Female)
- BMI >25
- Diagnosis: Newly diagnose cases of depression (mild to severe)
- HBA1C: Less than 5.7% (non-diabetic range)
You may not qualify if…
- Existing diabetes
- Acute illnesses like acute kidney injury, recent history of myocardial infarction, acute liver injury
- Intellectual disabilities or inability to understand due to any reason
- Presence of Psychiatric disorders other than depression
- Chronic kidney disease (eGFR < 45 mL/min/1.73 m²).
- Use of any psychotropic medication within the past 6 months.
Where it is running
- Fazaia Rurh Pfau Medical College — Karachi, Sindh, Pakistan (enrolling)
- Fazaia Ruth Pfau Medical College — Karachi, Sindh, Pakistan (enrolling)
Full record on ClinicalTrials.gov
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