Prostate Ablation Registry and Database for Information, Surveillance, and Evaluation (PARADISE)

Recruiting now

Conditions studied: Prostate Cancer

In brief

Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer of men in the world. In 2023 alone, it is estimated that 288,300 US men will be diagnosed with prostate cancer and 34,700 will die from the disease despite the approval of multiple systemic agents. Due to advances in screening and imaging technology, PCa is now detected much earlier in its disease course. Prostate gland ablation for prostate cancer might provide the option for a "middle" ground between active surveillance (AS) and radical therapy by destroying prostate cancer in a minimally invasive or non-invasive fashion and thus limiting the morbidity. This treatment strategy is increasingly being offered to patients due to low morbidity but the data on long term oncologic efficacy and side effect profile is lacking for such a treatment strategy. The purpose of this study is to create a database and prospective registry for data collection on patients with prostate cancer undergoing prostate ablation for the management of prostate cancer. Patients with biopsy-proven prostate cancer of any Gleason Grade will be entered into the registry as long as prostate ablation is used as the prostate cancer management modality. Historical data from 2017 to the present time will be added through chart review. Current and future patient data will be collected through chart review during the subject's clinical care. Only data available in the electronic medical record will be collected and no additional data will be collected for research purposes. No biospecimens will be collected, and there are no physical risks from study participation.

Key facts

Study ID

NCT06705803

Run by

University of Chicago

People needed

3000

Starts

2024-06-21

Expected to finish

2029-06-01

Last updated by the study team

2026-02-02

Who can join

Age: 22 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male sex
• ≥22 years of age
• Histologic diagnosis of prostate cancer
• Scheduled to undergo or have already undergone ablation of the prostate as part of routine clinical care or any ongoing clinical trials
• Prostate ablation performed with any of the following energy sources: cryotherapy, high-intensity focused ultrasound, irreversible electroporation, laser, microwave, radiofrequency ablation, or photodynamic therapy. Newer methods and instrumentation continue to be developed to ablate tissue, and these energy sources can be entered into the registry as clinical use begins

You may not qualify if…

• Under 21 Years of age.

Where it is running

• The University of Chicago — Hyde Park, Illinois, United States (enrolling)
• The University of Cinncinatti — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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