A Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity, Overweight, Chronic Weight Management

In brief

Phase 2 clinical study will evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of various aleniglipron (GSBR-1290) dose regimens compared with placebo in participants living with obesity or overweight with ≥ 1 weight-related comorbidity, in addition to diet and exercise, over a 44-week period.

Key facts

Study ID

NCT06703021

Run by

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

People needed

85

Starts

2024-12-20

Expected to finish

2026-01-12

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed informed consent
• BMI ≥30 kg/m2 or BMI ≥27.0 kg/m2 and previous/current diagnosis of ≥ 1 obesity related comorbidity

You may not qualify if…

• Previous documented diagnosis of diabetes mellitus
• Self-reported change in body weight >5% within 3 months before Screening
• Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty, if performed >1 year prior to screening)
• Use of medications intended to promote weight loss, within 6 months prior to Screening

Where it is running

• ACCESS II Research Site — Glendale, California, United States
• ACCESS II Research Site — Montclair, California, United States
• ACCESS II Research Site — Valparaiso, Indiana, United States
• ACCESS II Research Site — West Des Moines, Iowa, United States
• ACCESS II Research Site — Medford, Oregon, United States
• ACCESS II Research Site — East Greenwich, Rhode Island, United States
• ACCESS II Research Site — North Charleston, South Carolina, United States
• ACCESS II Research Site — Dallas, Texas, United States
• ACCESS II Research Site — San Antonio, Texas, United States
• ACCESS II Research Site — West Jordan, Utah, United States

Full record on ClinicalTrials.gov

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