Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in ICU Patients
Recruiting now · Not applicable
Conditions studied: Atelectasis, Postoperative, Hypoxia, Critical Illness
In brief
Atelectasis, hypoxemia, and ineffective sputum clearance are common problems in ICU patients. Continuous High-Frequency Oscillation (CHFO) is often considered to have a protective effect on the lungs. CHFO provides effective gas exchange at supraphysiological frequencies while minimizing pressure fluctuations, producing tidal volumes smaller than dead space, and adjusting around a continuously expanding pressure to optimize end-expiratory lung volume (EELV), thereby improving lung function by achieving and maintaining lung recruitment. However, the physiological effects and safety of CHFO in awake critically ill patients are still lacking relevant research. The objective of this study is to evaluate the comfort, safety, and efficacy of CHFO in awake critically ill patients.
Key facts
- Study ID
- NCT06702813
- Run by
- Shanghai Zhongshan Hospital
- People needed
- 45
- Starts
- 2024-11-19
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2024-11-25
Who can join
Age: 2 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients older than 18 and younger than 90 years;
- Admitted to the ICU after December 1, 2024, who are alert, with a GCS of 15, normal comprehension, and able to communicate clearly through speech or writing.
- Patients with atelectasis, who are receiving oxygen therapy, high-flow oxygen, or are on a ventilator via tracheostomy.
- Signed informed consent for MetaNeb treatment.
You may not qualify if…
- Refusal to participate in the proposed study.
- Age < 10 years;
- Pregnancy;
- Significant hemodynamic instability defined as an increase of more than 20% in catecholamine doses in the last hour, despite optimization of blood volume, for a target mean blood pressure between 65 and 75 mmHg.
- Participation in another trial within 30 days prior to meeting eligibility criteria;
- Severe chronic respiratory disease requiring long-term oxygen therapy or home mechanical ventilation;
- Pneumothorax. With a clear tracheoesophageal fistula
Where it is running
- Zhongshan Hospital, Fudan University — Shanghai, Shanghai Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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