Dexmedetomidine and Magnesium Sulfate in the Reduction Cognitive Dysfunction in Geriatrics

Recruiting now · Phase 1

Conditions studied: Mental Disorder

In brief

Magnesium sulfate is considered a neuroprotective drug and has been studied in various applications. Recently, it has drawn the attention of anesthesiologists, resulting in numerous publications about its role in anesthesiology. Magnesium sulfate is suggested to exert its neuroprotective effect by preventing excitotoxicity. in the clinical setting, intraoperative magnesium sulfate attenuated POCD. Furthermore, postoperative emergence agitation was significantly reduced in pediatric patients who received intraoperative magnesium sulfate during adenotonsillectomy. The aim of this study The aim of this work is to compare the protective effect of intraoperative dexmedetomidine with magnesium sulfate against developing POCD and to study their effect on serum level of CRP; the marker of neuronal degeneration.

Key facts

Study ID

NCT06702488

Run by

Fayoum University

People needed

58

Starts

2024-11-21

Expected to finish

2025-05-15

Last updated by the study team

2024-11-25

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA physical status I, II and ⅠⅠⅠ
• patients undergoing open abdominal surgery under general anesthesia

You may not qualify if…

• Elderly patients with preoperative MoCA Score below 26.
• Operation time more than 4 hours to prevent excessive dosage of magnesium sulfate.
• BMI > 35 kg m-2

Where it is running

• Dexmedetomidine — Al Fayyum, Egypt (enrolling)

Full record on ClinicalTrials.gov

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