Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals
Starting soon · Not applicable
Conditions studied: Osteo Arthritis Knee
In brief
This pilot study aims to investigate the viability of using a smartwatch-based electrodermal activity (EDA) sensor to capture enough EDA signal to quantitatively assess pain in osteoarthritis subjects and test the feasibility of its methods and procedures for later use in subsequent larger-scale studies.
Key facts
- Study ID
- NCT06701461
- Run by
- Dartmouth-Hitchcock Medical Center
- People needed
- 15
- Starts
- 2026-08-01
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2026-03-06
Who can join
Age: 50 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Kellgren-Lawrence Grade >= 3
You may not qualify if…
- Inflammatory arthropathy (e.g., rheumatoid arthritis), BMI >=35
- Control subjects:
- Exclusion Criteria:
- Complaints of lower extremity joint pain
- Known diagnosis of knee osteoarthpathy
- Prior history of knee surgery, knee injections, or injury to knee joints (e.g., meniscus tears, ligamentous injuries), BMI >=35
- Both groups, exclusion:
- Subjects with chronic heart problems, including, but not limited to, chronic hypertension, heart palpitations, a weak or irregular heartbeat, or a previous heart attack,
- Subjects taking the following drugs within 12 hours of the experiment or during the experiment: caffeine, alcohol, psychoactive drugs, nicotine or marijuana, other recreational drugs, and medicine of any kind that is not normally taken daily. Such medications include;
- NSAIDs
- Acetaminophen
- Steroidal anti-inflammatory agents
- Bronchodilators
- Appetite suppressants
- Lipase inhibitors
- Women who are currently pregnant
- Subjects with Raynaud's syndrome
- Subjects with any of the following conditions: active skin lesions where EDA sensors are, vertigo or dizziness, and anyone with postural orthostatic tachycardia syndrome (POTS), peripheral neuropathy, seizure disorders, methicillin-resistant staphylococcus aureus (MRSA), impaired circulation, medical implants, open skin lesions, chronic eczema on hands where EDA and electrical stimulator's electrodes are attached, diabetes, and epilepsy.
- Participants who have a skin sensitivity to metals, have a pacemaker or defibrillator, or have recent head trauma within the past two weeks (even without loss of consciousness)
- Participants who cannot feel physical pain or have a history of self-harm
Where it is running
- Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
Full record on ClinicalTrials.gov
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