Molecular Genetic Mechanisms of Infantile Epilepsies and the Impact of Genetic Diagnosis

Recruiting now · Not applicable

Conditions studied: Neonatal Epilepsy, Infantile Epilepsy

In brief

The goal of this study is to discover new genetic causes of infantile epilepsies and evaluate the impact of these discoveries on infants with epilepsy and their families.

Key facts

Study ID

NCT06701084

Run by

Boston Children's Hospital

People needed

600

Starts

2021-09-02

Expected to finish

2029-11-01

Last updated by the study team

2026-04-27

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Seizure onset at less than 12 months of age
• Enrollment within 6 weeks of seizure-related presentation
• Patient at Boston Children's Hospital

You may not qualify if…

• Simple febrile seizures
• Acute provoked seizures (e.g., due to sepsis, hemorrhage, electrolyte abnormality, cerebral infarction, hypoxic ischemic encephalopathy, non-accidental injury)
• Genetic or acquired cause of epilepsy already identified, including brain magnetic resonance imaging findings consistent with a specific genetic etiology (e.g., tuberous sclerosis complex)
• Deceased prior to enrollment
• Parent Criteria Inclusion Criteria - Parent of eligible infant (see above)
• Exclusion Criteria
• Not the legal guardian of the eligible infant

Where it is running

• Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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