Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation

Recruiting now · Phase 4

Conditions studied: Infertility, Female

In brief

The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro fertilization. The aim of the long Clomid protocol is to intensify stimulation of the ovaries and reduce both cost and injection burden for patients. Participants will be randomized to receive the long Clomid protocol vs. the typical protocol involving Clomid only for 5 days followed by growth hormone-releasing hormone (GnRH) antagonist. The primary outcome the investigators will evaluate will be the number of mature eggs retrieved.

Key facts

Study ID

NCT06701071

Run by

University of Southern California

People needed

120

Starts

2025-06-01

Expected to finish

2028-06-01

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older, up to 44. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing IVF
• Must meet POSEIDON criteria based on clinic evaluation
• Female partner: Antral follicle count of 2 or more and age <45 at time of stimulation start
• Male partner/sperm source: Cannot be azoospermic
• Planning freeze-all cycle (regardless of blastocyst or cleavage stage culture) or fresh transfer if randomized to short Clomid group
• Planning 36-hour trigger window

You may not qualify if…

• Normal ovarian reserve or good response
• Allergy or adverse reaction to Clomid
• Minimal stimulation protocols
• History of prior premature ovulation

Where it is running

• HRC Fertility — Pasadena, California, United States (enrolling)

Full record on ClinicalTrials.gov

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