Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

Enrolling by invitation

Conditions studied: Brain Activity Related to Opioid Administration, Brain Activity Related to Drug Liking

In brief

The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain. The investigators also aim to understand how this EEG biomarker is connected to patient perception to drug liking.

Key facts

Study ID

NCT06699953

Run by

Stanford University

People needed

20

Starts

2025-02-04

Expected to finish

2027-12-31

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years old or above (male and female)
• American Society of Anesthesiologists (ASA) physical status classification of I, II or III
• Candidates scheduled for general surgical procedures under general anesthesia and receive fentanyl for surgery

You may not qualify if…

• Craniofacial abnormalities
• Known or suspected difficult intubation or mask ventilation
• Known or suspected need for rapid sequence induction and intubation
• Body mass index above 45 kg/m2
• Allergies to fentanyl
• History of obstructive sleep apnea requiring CPAP
• History of obstructive or restrictive lung disease
• Opiate use within 24 hours
• History of opiate abuse within the last 3 years
• Known or suspected severe chronic pain condition that require use of opiates or limit daily activities
• MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body

Where it is running

• Stanford Hospital — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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