Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient

Recruiting now · Phase 4

Conditions studied: Dental Caries

In brief

This clinical trial aims to learn more about the working mechanism of an antimicrobial agent used to manage dental caries, especially in young, uncooperative children. It will also provide a deeper insight into different products of the same agent and its effectiveness in Arresting dental caries. The main questions it aims to answer are: What is the clinical impact of silver diamine fluoride application in caries-active children? What is the antimicrobial effect of silver diamine fluoride in oral microbial inhabitants? Researchers will compare silver diamine fluoride (SDF)only and silver diamine fluoride+ potassium iodide(SDF+KI) to see which materials substantially affect on dental caries and oral microbial inhabitants Participants/Parent will: The parent will fill out a comprehensive data sheet for the child (childhood and current dental and medical history) Visit the dental clinic to Receive one of 2 (SDF or SDF+KI) treatment applications once Visit the clinic a 2nd time for a 2-4 week Treatment Follow-up Go through the sample collection process twice( pre- and 2-4 weeks post- Treatment) Sample collection including (Saliva- Biofilm and caries tissue sample)

Key facts

Study ID

NCT06699199

Run by

King Abdulaziz University

People needed

50

Starts

2023-11-01

Expected to finish

2025-06-30

Last updated by the study team

2025-03-06

Who can join

Age: 4 and older, up to 12. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Healthy patients.
• Patients within 4-10 years of age.
• The presence of at least one deciduous tooth with a caries lesion that is directly accessible (cavitates)

You may not qualify if…

• Presentation of irreversible pulpititis or necrosis• The extensive lesion was restored.
• The surface of the lesion was hard and smooth.
• Children with inherited or systemic conditions.
• Children with a substantial medication history or those who have taken antibiotics within the previous three months.
• Children who have undergone topical fluoride treatment within the previous 2 weeks.

Where it is running

• University Dental hospital of King Abdulaziz University — Jeddah, Mecca Region, Saudi Arabia (enrolling)

Full record on ClinicalTrials.gov

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