The EEG Study Under Remimazolam Anesthesia in Children
Recruiting now
Conditions studied: Electroencephalography, Remimazolam, Child Neglect
In brief
The effect of Remimazolam on brain electrical activity. Previous studies have shown that in healthy male volunteers, EEG changes during Remimazolam infusion are characterized by an initial increase in the beta band and a later increase in the delta band. When monitoring the depth of anesthesia, the commonly used Bispectral Index in clinical practice was originally developed for propofol. Therefore, studies have shown that the correlation between the depth of sedation of benzodiazepines such as midazolam and Bispectral Index is weak. In contrast, the beta wave ratio is considered a more suitable EEG indicator for monitoring the sedative effect of Remimazolam. The above indicates that Remimazolam has a specific pattern of influence on EEG activity, especially in the regulation of anesthesia depth, with unique characteristics.
Key facts
- Study ID
- NCT06698705
- Run by
- Second Affiliated Hospital of Wenzhou Medical University
- People needed
- 60
- Starts
- 2024-11-22
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2025-02-06
Who can join
Age: 1 and older, up to 12. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- aged 1 years-12 years; 2, with American Society of Anesthesiologists (ASA) physical status I or II; 3, children requiring general anesthesia under remimazolam; 4, parents or legal guardians of children who volunteered to participate in the trial; And signed the informed consent form.
You may not qualify if…
- Congenital malformation or other genetic conditions that are thought to affect brain development ;
- History of severe heart, brain, liver, kidney and metabolic diseases ;
- Premature infants (≤32 weeks);
- Upper respiratory tract infection in the last two weeks. -
Where it is running
- The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University — Wenzhou, Zhejiang, China (enrolling)
Full record on ClinicalTrials.gov
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