Efficacy of Statins Among Major Depressive Disorder
Recruiting now · Phase 3
Conditions studied: Major Depressive Disorder, MDD
In brief
The goal of this clinical trial is to learn if drug Rosuvastatin 10 mg works to treat MDD in adults. It will also learn about the safety of Rosuvastatin 10 mg .The main questions it aims to answer are: Does Rusovastatin lower the score of The Montgomery Asberg Depression Rating Scale (MADRS) among adult participants with Major Depression Disorder ( MDD )? What medical problems do participants have when taking drug ABC? Participants will: Take Rosuvastatin 10 mg every day for 3 months Visit the clinic once every 4 weeks for checkups and tests Report any side effects for Rosuvastatin 10 mg and reassess the severity of depression using The Montgomery Asberg Depression Rating Scale (MADRS)
Key facts
- Study ID
- NCT06698666
- Run by
- Ain Shams University
- People needed
- 145
- Starts
- 2022-10-01
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-08-17
Who can join
Age: 20 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- aged between 20 and 45 years;
- diagnosis of current MDD, verified using the Structured Clinical Interview for DSM-IV Axis I Disorders, patient version (SCID-I/P);
- The Montgomery Asberg Depression Rating Scale (MADRS) score of 7 to 34, indicating mild to moderate depression;
- the ability to give informed consent and to comply with standard procedures;
- Males and females; and
- Stable pharmacological treatment for at least 2 weeks prior to enrolment (changes to medication dose or frequency of therapy excepted) if currently being treated.
You may not qualify if…
- lifetime or current SCID-I/P diagnosis of a psychotic disorder;
- lifetime SCID-I/P diagnosis of bipolar I or II disorder or alcohol dependence;
- acute or unstable systemic medical disorder;
- inability to comply with the requirements of informed consent or the study protocol;
- history of intolerance or allergy to study medications;
- Current pregnancy or breast feeding;
- Current regular use of statins, corticosteroids, or any other immunomodulatory agents; and
- Females on Contraception.
Where it is running
- El demerdash hospital — Cairo, Al Abbasia, Egypt (enrolling)
Full record on ClinicalTrials.gov
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