Effect of Human Urinary Kallidinogenase on Inflammatory Factors in Acute Ischemic Stroke (KIF-AIS)
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Acute Ischemic Stroke
In brief
The goal of this clinical trial is to explore the changes in the expression levels of inflammatory factors before and after the early treatment of Human Urinary Kallidinogen (HUK) in the acute ischemic stroke. It will also learn about the correlation between inflammatory factors and AIS prognosis, in order to clarify the efficacy and safety of Urinary Kallidinogen in the acute phase of AIS.
Key facts
- Study ID
- NCT06696703
- Run by
- First Affiliated Hospital of Harbin Medical University
- People needed
- 200
- Starts
- 2024-01-01
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2024-11-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis as acute ischemic stroke according to the Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2018;
- First clinical onset or previous presence of cerebral infarction without severe sequelae（Premorbid mRS ≤2）
- Age≥18 years, male or female;
- 3≤Baseline NIHSS≤25;
- Written informed consent obtained from the patient or legally responsible person.
You may not qualify if…
- Cerebral hemorrhage and the acute phase of other hemorrhagic diseases；
- Previously allergic or intolerant to injectable HUK；
- Used ACEI drugs prior to medication and less than 5 half-lives of the drug (according to the specific drug instructions) or received ACEI drugs during the study period;
- Stent surgery after the AIS onset or planned interventional therapy;
- Pregnancy, lactation or planned pregnancy；
- Life expectancy of less than 3months or inability to complete the study for other reasons；
- Unwilling to be followed up or poor compliance；
- Current participation in other clinical research;
- Other causes of AIS (such as dissection, vasculitis, pre-thrombotic lesions, drug abuse).
Where it is running
- Zhongling Zhang — Harbin, Heilongjiang, China (enrolling)
Full record on ClinicalTrials.gov
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