Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS

Recruiting now · Not applicable

Conditions studied: ARDS: Acute Respiratory Distress Syndrome

In brief

This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.

Key facts

Study ID

NCT06696638

Run by

XiaoJing Zou,MD

People needed

26

Starts

2025-01-01

Expected to finish

2026-12-31

Last updated by the study team

2025-01-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with ARDS according to the 2023 global new definition of ARDS.
• Age ≥ 18 years.

You may not qualify if…

• Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
• Pulmonary interstitial disease.
• Uncorrected shock of various types.
• Intracranial hypertension.
• Pregnant and postpartum women.

Where it is running

• Wuhan Union hospital — Wuhan, Hubei, China (enrolling)

Full record on ClinicalTrials.gov

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