Supplementation With Beetroot Juice to Prevent Contrast Associated Nephropathy During Hospitalization for Acute Coronary Syndrome Without ST Elevation

Recruiting now · Not applicable

Conditions studied: Non ST Segment Elevation Acute Coronary Syndrome, Contrast Induced Nephropathy

In brief

The goal of this study is to compare the possible beneficial effect of beetroot juice supplementation versus the usual management during hospitalization to prevent contrast-induced nephropathy after cardiac catheterizations. The study includes patients diagnosed with non-ST elevation acute coronary syndrome with a possible indication for catheterism and high risk of kidney injury related to iodinated contrast. The intervention group will drink 500 mL (2 glasses daily, at breakfast and dinner) of beetroot juice added to the usual diet for 7 days or until hospital discharge and will receive the recommendation to maintain a diet rich in inorganic nitrates. The control group will receive the usual diet and recommendations. In both cases, other therapies will be prescribed to prevent contrast-induced nephropathy (hydration and statins) if there is no contraindication. Our hypothesis is that a compound present in beetroot juice, inorganic nitrates, can prevent the deterioration of kidney function related to contrast due to its vasodilatory effect, in addition to improving the subsequent prognosis of coronary heart disease due to its anti-inflammatory and antiproliferative effects, protector of the endothelium and inhibitor of platelet aggregation. Beetroot juice could also be beneficial in this context due to the antioxidant effect of the betalains it contains.

Key facts

Study ID: NCT06695429
Run by: Hospital General Universitario Santa Lucia
People needed: 130
Starts: 2024-10-07
Expected to finish: 2027-09-30
Last updated by the study team: 2025-05-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Diagnosis of Acute Coronary Syndrome without persistent ST segment elevation, with recommendation for invasive management according to the actual Clinical practice guidelines
At least moderate or high risk of nephropathy associated with iodinated contrast (Mehran score (without including contrast volume) ≥ 6).

You may not qualify if…

<18 years old or without capacity to give consent.
Refusal to participate in the study.
Known hypersensitivity to beetroot or any of its allergens.
Pregnant.
Inability to take food orally
Serious illnesses (not related to ACS or kidney failure), which limits their life expectancy to a period predictably less than 1 year.
On dialysis or predialysis at the time of inclusion.
ACS with persistent ST segment elevation before inclusion.
Shock or inotrope dependence at the time of inclusion
PCI already performed before inclusion.
Patients receiving intravenous nitroglycerin for > 1 hour before inclusion

Where it is running

Hospital Universitario Santa Lucía — Cartagena, Spain (enrolling)

Full record on ClinicalTrials.gov

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