A Study of Mobility Outcomes in Post-Pulmonary Embolic Disease
Recruiting now · Not applicable
Conditions studied: Pulmonary Embolism
In brief
The purpose of this study is to develop a unique structure and delivery of home-based exercise through multidisciplinary expertise of cardiovascular medicine specialists and cardiac physiologists using an Interactive Care Plan.
Key facts
- Study ID
- NCT06695247
- Run by
- Mayo Clinic
- People needed
- 100
- Starts
- 2025-07-14
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-08-10
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Acute intermediate-risk PE, defined as:
- Intraluminal filling defect in segmental or larger vessels on computed tomography pulmonary angiography or high-probability ventilation/perfusion scan AND
- Evidence of right ventricular enlargement by computed tomography (RV to LV ratio >1) or echocardiography; and/or right ventricular dysfunction by transthoracic echocardiography. These imaging characteristics must be in the setting of acute PE rather than explained by a prior chronic condition.
- Acute high-risk PE, defined as:
- Intraluminal filling defect in segmental or larger vessels on computed tomography pulmonary angiography or high-probability ventilation/perfusion scan AND
- Evidence of right ventricular enlargement by computed tomography (RV to LV ratio >1) or echocardiography; and/or right ventricular dysfunction by transthoracic echocardiography. These imaging characteristics must be in the setting of acute PE rather than explained by a prior chronic condition; AND
- Hypotension (systolic blood pressure < 90 mm Hg sustained for more than 15 minutes; or requiring vasopressors) or cardiogenic shock due to acute pulmonary embolism.
You may not qualify if…
- Inability to ambulate independently, which is necessary to perform 6MWD (may be self-reported or as deemed by physical therapy during inpatient evaluation).
- If patient requires supplemental oxygen during ambulation, this does not exclude patient from participation and will be noted during eCRF.
- Prior history of pulmonary embolism
- History of CTEPH or pulmonary arterial hypertension
- Unable to read a questionnaire in English
- Unable to return for baseline, 3- or 6-month follow-up visit
- Pregnancy-associated pulmonary embolism
- Life expectancy <1 year based on comorbidities
- Unable/unwilling to provide informed written consent
Where it is running
- Mayo Clinic Rochester — Rochester, Minnesota, United States (enrolling)
Full record on ClinicalTrials.gov
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