Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease
Recruiting now
Conditions studied: Chronic Kidney Disease(CKD), Type 1 Diabetes (T1D)
In brief
This is a cross-sectional study in patients with Type 1 diabetes (TID) and chronic kidney disease (CKD) to test if time in range (TIR) affects the degree of hyperglycemia required for monocyte activation, podocyte injury, and assess if monocyte activation is attenuated by glucagon-like peptide (GLP-1) agonist treatment ex vivo.
Key facts
- Study ID
- NCT06694558
- Run by
- The Cleveland Clinic
- People needed
- 60
- Starts
- 2025-03-01
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-07-08
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- T1D CKD subjects:
- Adults, males or females diagnosed with T1D
- Age 18-65 years
- Diagnosed with CKD (eGFR 60-90 ml/min/1.73 m2)
- Diagnosed with albuminuria (UACR 30-500 mg/g)
- On insulin injections or pump
- On CGM
- Based on baseline CGM metrics, the investigators will stratify subjects to 2 groups Group A (Lower TIR group): TIR<60%, A1c 7.5-9.5 Group B (Higher TIR group): TIR>70% A1c 5.0-7.0
- Controls: T1D subjects without CKD
- Adults, males or females diagnosed with T1D
- Age 18-65 years
- No CKD (eGFR >90 ml/min/1.73 m2)
- No albuminuria (UACR <30 mg/g)
- On insulin injections or pump
- On CGM
- Based on baseline CGM metrics, the investigators will stratify subjects to 2 groups Group A (Lower TIR group): TIR<60%, A1c 7.5-9.5 Group B (Higher TIR group): TIR>70% A1c 5.0-7.0
You may not qualify if…
- Hemoglobin <9
- On GLP-1 agonist or DPP4 inhibitor or sodium-glucose co-transporter-2 inhibitors use within 30 days
- pregnancy or plans to become pregnant
- On steroids
- Diagnosed with cancer, immunosuppression/autoimmune conditions
- Reported heavy alcohol use or recreational drug use
- Any condition which jeopardizes patient safety or affects monocytes at physician's discretion
Where it is running
- Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.