Sedentary or Exercised : Neuromuscular and Immunometabolic Observations and Retrospection

Recruiting now · Not applicable

Conditions studied: Aging

In brief

The distinction between healthy and pathological ageing has given rise to the vitality capacity concept. Underlying the physiological aspect of ageing, vitality capacity is reflected in the neuromuscular function, metabolism, and immune and stress response. The three domains seem to deteriorate with age, except among individuals who have maintained physical activity throughout their lives. Furthermore, immune cells, particularly T lymphocytes, appear to play a key role in each dimension of vitality capacity, as well as in the mice ageing pathway. Investigators sought to determine the effect of lifelong physical activity on vitality capacity, and especially on T cell metabolism. In this optic, fourty healthy participants over the age of 55 will be allocated to two groups: 20 who have maintained physical activity for the past 30 years, and 20 who have not. Each participant's vitality capacity will be deeply tested and compared to their physical activity background.

Key facts

Study ID
NCT06692543
Run by
Centre Hospitalier Universitaire de Nice
People needed
60
Starts
2025-04-14
Expected to finish
2028-12-01
Last updated by the study team
2026-05-22

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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