Caspofungin for Pneumocystis Pneumonia in PLWHIV.

Recruiting now

Conditions studied: HIV-1-infection, Pneumocystis Pneumonia

In brief

Pneumocystis jirovecii pneumonia is a significant concern in peaple with HIV/AIDS, often severe and potentially fatal. While trimethoprim/sulfamethoxazole remains the primary treatment, safety concerns exist with alternative options. Research on Pneumocystis jirovecii's beta-D glucan composition has prompted investigations into echinocandins like caspofungin, showing promise in murine models and some positive results in human studies. Evaluating caspofungin's efficacy through observational studies is crucial due to safety advantages over current treatments and limited documented data.

Key facts

Study ID

NCT06691321

Run by

Instituto Nacional de Enfermedades Respiratorias

People needed

60

Starts

2023-08-01

Expected to finish

2025-09-01

Last updated by the study team

2024-11-19

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of probable or proven PCP, according to its diagnostic classification (refer to classification at the end of this section).
• Have clinical laboratory and virological diagnostic laboratory studies at the time of admission.
• Classification criteria for Pneumonia by P. jirovecii according to Robert-Gangneux et al.:
• Proven: Confirmation by pathology or microbiology. Possible: Presence of three out of four clinical or radiological criteria. Probable: Presence of one clinical or radiological criterion without another identified microorganism.

You may not qualify if…

• With a treatment switch to caspofungin after day 7 of treatment initiation (applies only to group B).
• Patients who have developed an additional opportunistic lung infection during their hospitalization, other than cytomegalovirus pneumonitis or SARS-CoV-2 pneumonia.

Where it is running

• Center for Research in Infectious Diseases (CIENI) — Mexico City, Tlalpan, Mexico (enrolling)

Full record on ClinicalTrials.gov

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