PeRfusiOn Post tHrombEcTomy (PROPHET)

Recruiting now

Conditions studied: Stroke, Acute, Ischemic

In brief

Endovascular mechanical thrombectomy is the standard of care for treating patients with a large-vessel occlusion acute ischemic stroke. However, in more than half of these patients, remaining distal vessel occlusions limit the benefit of this therapy. Currently the detection of residual vessel occlusions and the decision for further treatment by the operator is based on the 2D digital subtraction angiography (DSA) images. However, this technique has several limitations. Recently, a new imaging technique, with the possibility to acquire 3D time-resolved perfusion images directly in the operating room was introduced (the flat-panel detector computed tomography perfusion imaging, FDCTP). It can overcome the spatial limitations of 2D DSA, but the details on clinical validation and utility of FDCTP are currently lacking.

Key facts

Study ID: NCT06691230
Run by: Insel Gruppe AG, University Hospital Bern
People needed: 279
Starts: 2024-11-01
Expected to finish: 2028-02-28
Last updated by the study team: 2024-11-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Informed consent as documented by a signature
The patients received mechanical thrombectomy or there was the intention to perform endovascular treatment, but only diagnostic angiography was performed.
Patients received FDCTP as clinically indicated by the treating physician.

You may not qualify if…

Inability to give consent due to insufficient knowledge of the project language
Inability to follow the clinically indicated visit at 90 days after the index stroke (e.g. patients living abroad).

Where it is running

University Hospital Bern — Bern, Switzerland (enrolling)
University Hospital Basel — Basel, Switzerland

Full record on ClinicalTrials.gov

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