Improving 24-hour Blood Pressure Stability in Spinal Cord Injury With Low Oxygen Therapy
Recruiting now · Phase 1/Phase 2
Conditions studied: Spinal Cord Injury
In brief
This study examines the effects of low oxygen therapy (LOT) on the stability of 24-hour blood pressure in persons with chronic cervical spinal cord injury. This study will examine if brief episodes of breathing lower oxygen, termed low oxygen therapy (LOT), which has been shown to enhance autonomic nervous system activity, can improve blood pressure stability in individuals with spinal cord injury. The research team will assess 24-hour blood pressure, as well as cardiac, vascular, and autonomic function before and after a 4-day LOT treatment intervention. This study will advance current understanding of treatments to mitigate cardiovascular disease risk in people with spinal cord injuries.
Key facts
- Study ID
- NCT06691165
- Run by
- Glen Foster
- People needed
- 10
- Starts
- 2025-10-23
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-11-18
Who can join
Age: 19 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Are between the ages of 19-65
- Living with a chronic cervical (at or above T1) spinal cord injury of at least one year
- Are fluent in english
You may not qualify if…
- High-cervical injuries requiring ventilator assistance to breathe will be excluded on account of the necessity of the facemask for the delivery of hypoxia
- Unhealed fracture, contracture, or pressure sore that might interfere with participants' ability to complete the protocol
- Additional concurrent neurological conditions (e.g., multiple sclerosis, Parkinson disease, stroke or brain injury)
- Uncontrolled cardiovascular or pulmonary disease
- Severe neuropathic pain
- Severe recurrent autonomic dysreflexia
- History of seizure disorders
- Known pregnancy
Where it is running
- UBC Okanagan — Kelowna, British Columbia, Canada (enrolling)
- International Collaboration on Repair Discoveries (ICORD) — Vancouver, British Columbia, Canada (enrolling)
Full record on ClinicalTrials.gov
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