How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

Recruiting now · Not applicable

Conditions studied: Weight Management, Obesity, Exercise, Women, Gut Microbiome, Metabolome, Health, Gut Microbiota

In brief

This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.

Key facts

Study ID

NCT06691100

Run by

George Washington University

People needed

40

Starts

2024-10-16

Expected to finish

2027-10-16

Last updated by the study team

2025-07-24

Who can join

Age: 21 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Biological sex: female
• BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2
• Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)
• Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).

You may not qualify if…

• Biological sex: male
• BMI < 19 kg/m2 or > 40 kg/m2
• Currently pregnant, < 2 years postpartum, lactating
• Currently taking any herbal, fiber, or prebiotic supplement
• Current or 1-month before the study, taking oral or vaginal antibiotics
• Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.

Where it is running

• Milken Institute School of Public Health, The George Washington University — Washington D.C., District of Columbia, United States (enrolling)

Full record on ClinicalTrials.gov

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