E-cigarette Cessation in Adults Who Co-use Cannabis

Recruiting now · Phase 4

Conditions studied: Nicotine Dependence, Tobacco Use Disorder

In brief

The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Investigators are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive e-cigarette cessation treatment for 12 weeks. To qualify, participants must be between the ages of 18-40 and use both e-cigarettes and cannabis. Participants do not need to be interested in quitting cannabis to qualify. This study is being conducted at three sites: the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and MUSC Lancaster in Lancaster, SC.

Key facts

Study ID

NCT06688539

Run by

Medical University of South Carolina

People needed

105

Starts

2025-02-19

Expected to finish

2027-06-01

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between the ages of 18 and 40 years old
• Use e-cigarettes daily or near daily in the past month
• Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
• Be interested in quitting use of e-cigarettes
• Must be willing to take varenicline for the standard 12-week course of treatment
• Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (> 50 ng/ml)

You may not qualify if…

• Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
• Use of cigarettes on 10+ days in the past 30
• Currently pregnant or breastfeeding
• Current use of medications with smoking cessation efficacy
• Use of any medications that would interfere with varenicline

Where it is running

• MUSC Charleston — Charleston, South Carolina, United States (enrolling)
• MUSC Lancaster — Lancaster, South Carolina, United States (enrolling)
• Behavioral Health Services of Pickens County — Pickens, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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