A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013)

Completed · Phase 1

Conditions studied: Healthy

In brief

The goal of this study is to learn what happens to levels of nemtabrutinib in a person's body over time. Researchers will compare what happens to nemtabrutinib in the body when it is given with or without another medicine called itraconazole.

Key facts

Study ID

NCT06688045

Run by

Merck Sharp & Dohme LLC

People needed

15

Starts

2023-10-30

Expected to finish

2024-01-06

Last updated by the study team

2024-11-14

Who can join

Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• The key inclusion criteria include but are not limited to the following:
• Is in good health based on medical history, physical examination, vital sign (VS) measurements, electrocardiograms (ECGs) and laboratory safety tests performed before allocation.
• Has a body mass index (BMI) of18 to 32 kg/m\^2 (inclusive)

You may not qualify if…

• The key exclusion criteria include but are not limited to the following:
• Has a history of clinically significant endocrine, gastrointestinal (GI), cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases.
• Has a history of cancer (malignancy).

Where it is running

• Labcorp Clinical Research Unit Inc. (Site 0001) — Honolulu, Hawaii, United States

Full record on ClinicalTrials.gov

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