A Study of Calderasib (MK-1084) Human Absorption, Distribution, Metabolism, and Excretion in Healthy Adult Participants (MK-1084-006)

Completed · Phase 1

Conditions studied: Healthy

In brief

The purpose of this study is to learn what happens to calderasib in a healthy person's body over time and how it is cleared from the body.

Key facts

Study ID

NCT06687759

Run by

Merck Sharp & Dohme LLC

People needed

8

Starts

2024-06-26

Expected to finish

2024-08-07

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Key inclusion criteria include but are not limited to the following:
• Is in good health based on medical history, physical examination,vital signs measurements, and electrocardiogram (ECG)s performed before randomization.
• Has a body mass index (BMI) 18 to 32 kg/m2, inclusive, at screening

You may not qualify if…

• The key exclusion criteria include but are not limited to the following:
• Has a history of clinically significant endocrine, gastrointestinal (GI), cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases.
• Has a history of cancer.

Where it is running

• Fortea CRU Madison (Site 0001) — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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